In cases of overdose, standard supportive measures really should be adopted as demanded. Renal dialysis isn't predicted to accelerate clearance as sildenafil is highly sure to plasma proteins and It's not at all removed in the urine.
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Viagra had no impact on saquinavir pharmacokinetics. A more powerful CYP3A4 inhibitor such as ketoconazole or itraconazole may be envisioned to have higher outcome than that seen with saquinavir. Populace pharmacokinetic knowledge from clients in clinical trials also indicated a discount in sildenafil clearance when it absolutely was co-administered with CYP3A4 inhibitors (including ketoconazole, erythromycin, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].
are allergic to sildenafil, as contained in VIAGRA and REVATIO, or any of your elements in VIAGRA. See the stop of the leaflet for a whole list of elements in VIAGRA.
Doctors should really recommend individuals in the likely for VIAGRA to reinforce the hypertension lowering effect of alpha-blockers and anti-hypertensive medicines. Concomitant administration of VIAGRA and an alpha-blocker may possibly bring on symptomatic hypotension in some individuals.
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The inhibition of PDE5 in some of these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of NO observed in vitro, an inhibition of platelet thrombus development in vivo and peripheral arterial-venous dilatation in vivo.
VIAGRA has systemic vasodilatory Attributes and will even further lower blood pressure in sufferers having antihypertensive medications.
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